Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 11/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22784386 | 1.00 | CHRM3 (0.64) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22784184 | 0.94 | CHRM3 (0.66) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22784179 | 0.94 | CHRM3 (0.66) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| Hydrochloric Acid SCHEMBL29560765 | 0.93 | CHRM3 (0.65) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22784237 | 0.90 | CHRM3 (0.68) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL23561888 | 0.90 | CHRM3 (0.70) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22776286 | 0.85 | CHRM3 (0.58) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22776285 | 0.85 | CHRM3 (0.58) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22777096 | 0.83 | CHRM3 (0.68) | CHRM3KCNH2CHRM1CHRM2CHRM5 | |
| SCHEMBL22784309 | 0.83 | CHRM3 (0.68) | CHRM3KCNH2CHRM1CHRM2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |