Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426496 | 0.85 | GRM5 (0.44) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2485416 | 0.80 | GRM5 (0.48) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13660375 | 0.78 | GRM5 (0.42) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13482129 | 0.76 | GRM5 (0.44) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19152974 | 0.73 | GRM5 (0.48) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22787173 | 0.73 | BRD4 (0.51) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL29526371 | 0.73 | BRD4 (0.51) | GRM5SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4423448 | 0.72 | GRM5 (0.54) | GRM5SMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL4275594 | 0.71 | GRM5 (0.61) | GRM5ALDH1A1NPSR1TSHRKDM4E | |
| SCHEMBL15840867 | 0.71 | CYP1A2 (0.50) | GRM5SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020248065-A1 | UNSATURATED HETEROCYCLOALKYL AND HETEROAROMATIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2020-12-17 | — | — | WO | disclosed |