Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789758 | 0.86 | PTPN11 (0.41) | PTPN11EGFRKCNH2 | |
| SCHEMBL22789666 | 0.83 | PTPN11 (0.50) | PTPN11MAPK14BRAFEGFRKCNH2 | |
| SCHEMBL24282700 | 0.83 | PTPN11 (0.46) | PTPN11TGFBR1MAPK14KCNH2TRPA1 | |
| SCHEMBL24282635 | 0.80 | PTPN11 (0.46) | PTPN11EGFRKCNH2 | |
| SCHEMBL24282647 | 0.79 | PTPN11 (0.44) | PTPN11EGFRKCNH2 | |
| SCHEMBL23186796 | 0.78 | PTPN11 (0.41) | PTPN11EGFRKCNH2FASN | |
| SCHEMBL22789760 | 0.76 | PTPN11 (0.63) | PTPN11EGFRKCNH2 | |
| SCHEMBL24282661 | 0.76 | PTPN11 (0.52) | PTPN11EGFRKCNH2 | |
| SCHEMBL24282659 | 0.76 | PTPN11 (0.43) | PTPN11EGFRKCNH2 | |
| SCHEMBL24282630 | 0.75 | PTPN11 (0.54) | PTPN11EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3984999-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | Beijing Shenogen Pharma Group Ltd. (CN) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249079-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | 北京盛诺基医药科技股份有限公司 | 2020-12-17 | — | — | WO | disclosed |