Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.49 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29525766 | 1.00 | ATR (0.49) | ATRATRIPGPR119PIK3CAPIK3R1 | |
| SCHEMBL6520863 | 0.89 | ATR (0.51) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL2489969 | 0.89 | ATR (0.51) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL4210198 | 0.89 | ATR (0.51) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL22774159 | 0.89 | ATR (0.52) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL22773893 | 0.85 | ATR (0.56) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL22773895 | 0.85 | ATR (0.56) | ATRATRIPPIK3CAPIK3R1MTOR | |
| SCHEMBL28933620 | 0.84 | ATR (0.43) | ATRGPR119PIK3CAPIK3R1MTOR | |
| SCHEMBL22790418 | 0.84 | ATR (0.43) | ATRGPR119PIK3CAPIK3R1MTOR | |
| SCHEMBL29526098 | 0.84 | ATR (0.43) | ATRGPR119PIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306623-A1 | PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-09-29 | — | — | US | disclosed |
| WO-2020249652-A1 | PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306623-A1 | PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS | MTOR, RICTOR, RPTOR | ATR 684/4885ATRIP 2959/4885GPR119 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.