Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.53 |
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | DRD4 | P21917 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.53 |
| ▸ | DRD1 | P21728 | 4/20 | 0.53 |
| ▸ | DRD5 | P21918 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26707055 | 0.85 | GAA (0.53) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL20230946 | 0.83 | DRD3 (0.52) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL2759552 | 0.83 | HRH4 (0.49) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL21673531 | 0.80 | DRD3 (0.44) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL21477154 | 0.80 | DRD3 (0.49) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL12217555 | 0.79 | HRH3 (0.49) | HRH3CYP1A2CYP2D6 | |
| SCHEMBL9908392 | 0.79 | HRH3 (0.53) | HRH3CYP1A2CYP2D6 | |
| SCHEMBL16256947 | 0.79 | SMN1; SMN2 (0.57) | DRD3DRD2DRD4HTR7DRD1 | |
| SCHEMBL12168263 | 0.79 | HRH3 (0.54) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL13368493 | 0.78 | RET (0.42) | DRD3DRD2DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |