⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279240 | 1.00 | — | — | |
| SCHEMBL2279242 | 1.00 | — | — | |
| SCHEMBL19844485 | 1.00 | — | — | |
| SCHEMBL12269886 | 0.76 | — | — | |
| SCHEMBL12424342 | 0.76 | — | — | |
| SCHEMBL3632061 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL21805918 | 0.73 | — | — | |
| SCHEMBL12927413 | 0.71 | — | — | |
| SCHEMBL903961 | 0.71 | KDM4E (0.34) | — | |
| SCHEMBL10067709 | 0.71 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634410-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20210309644-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-10988463-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2021-04-27 | — | — | US | disclosed |
| EP-3397631-B1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20200377482-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-12-03 | — | — | US | disclosed |
| US-10787438-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20200148669-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2020-05-14 | — | — | US | disclosed |
| US-20190106412-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2019-04-11 | — | — | US | disclosed |
| US-10174007-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180037575-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2018-02-08 | — | — | US | disclosed |
| US-9809579-B2 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors | PFIZER INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170183328-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. | 2017-06-29 | — | — | US | disclosed |
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |