Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24513988 | 0.99 | HRH3 (0.57) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL22794340 | 0.95 | HRH3 (0.61) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25110455 | 0.87 | HRH3 (0.47) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25109828 | 0.86 | HRH3 (0.48) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25110451 | 0.85 | CHKA (0.47) | HRH3KDM4EALDH1A1MAPTS1PR1 | |
| SCHEMBL25110506 | 0.85 | HRH3 (0.44) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25108883 | 0.85 | HRH3 (0.44) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25109774 | 0.84 | HRH3 (0.56) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL25110045 | 0.84 | KDM4E (0.44) | HRH3KDM4EALDH1A1MAPTPKM | |
| SCHEMBL22794084 | 0.84 | KDM4E (0.44) | HRH3KDM4EALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |