Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 16/20 | 0.60 |
| ▸ | SMARCA4 | P51532 | 16/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 17/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22794165 | 0.93 | SMARCA2 (0.58) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL30796567 | 0.88 | PBRM1 (0.57) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL22776334 | 0.88 | PBRM1 (0.57) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL29704294 | 0.87 | SMARCA2 (0.56) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL22777077 | 0.87 | SMARCA2 (0.56) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL22777154 | 0.86 | SMARCA2 (0.61) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL18081132 | 0.86 | SMARCA2 (0.68) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL22776616 | 0.85 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL29704275 | 0.85 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL22776619 | 0.85 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |