Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 16/20 | 0.48 |
| ▸ | SMARCA4 | P51532 | 16/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 18/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25111160 | 1.00 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL25111347 | 1.00 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL22794370 | 0.95 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL22794880 | 0.95 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL22794750 | 0.91 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL22794563 | 0.87 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL25110979 | 0.86 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL25109818 | 0.86 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL22794154 | 0.85 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1BRD4NR1I2 | |
| SCHEMBL25109657 | 0.84 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BRD4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |