SCHEMBL22797682

SCHEMBL22797682

CC1(C)c2cccc(Cl)c2C(=O)c2c(Cl)cccc21

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.46
PGR P06401 1/20 0.39
NSD2 O96028 2/20 0.37
BCHE P06276 1/20 0.37
DAO P14920 1/20 0.37
ADORA2A P29274 1/20 0.36
PDK2 Q15119 2/20 0.36
TGM2 P21980 1/20 0.36
LCK P06239 4/20 0.35
PDK4 Q16654 1/20 0.35
RET P07949 1/20 0.35
GRK5 P34947 1/20 0.35
TYRO3 Q06418 1/20 0.35
DYRK1B Q9Y463 1/20 0.35
PBRM1 Q86U86 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31591201 0.78 PDK2 (0.54) PGRADORA2APDK2
SCHEMBL19849934 0.78 PDK2 (0.54) PGRADORA2APDK2
SCHEMBL20806488 0.78 PDK2 (0.42) CES1PGRPDK2
SCHEMBL6036510 0.74 PTPRC (0.42) CES1PGRNSD2BCHEADORA2A
SCHEMBL20806542 0.72 PDK2 (0.39) PGRPDK2
SCHEMBL25124836 0.71 PDK2 (0.44) PGRPDK2
SCHEMBL20806341 0.71 PDK2 (0.44) PGRPDK2
SCHEMBL22920804 0.71 PDK2 (0.41) PGRADORA2APDK2
SCHEMBL21037625 0.71 PDK2 (0.44) PGRPDK2
SCHEMBL4585020 0.70 NSD2 (0.55) CES1NSD2BCHEDAOADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020248943-A1 NITROGEN-CONTAINING COMPOUND, ELECTRONIC COMPONENT AND ELECTRONIC DEVICE 陕西莱特光电材料股份有限公司 2020-12-17 WO disclosed