Sugi Predict

Sugi Predict / Compounds / SCHEMBL22798358

SCHEMBL22798358

SCHEMBL22798358

C[C@H](COc1ncc(C(F)(F)F)cc1Cl)NC(=O)c1ccnc(NC(=O)C2CC2)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SCN9A Q15858 3/20 0.44
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.40
▸ LMNA P02545 2/20 0.40
▸ POLB P06746 1/20 0.40
▸ ACACB O00763 3/20 0.39
▸ AURKA O14965 2/20 0.39
▸ LCK P06239 1/20 0.39
▸ IGF1R P08069 1/20 0.39
▸ EIF2AK2 P19525 1/20 0.39
▸ SYK P43405 1/20 0.39
▸ BMX P51813 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ BRAF P15056 2/20 0.38
▸ KDR P35968 2/20 0.38
▸ GSK3A P49840 2/20 0.38
▸ GSK3B P49841 2/20 0.38
▸ GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22798359 1.00 SCN9A (0.44) SCN9AMEN1KMT2ASMN1; SMN2LMNA
SCHEMBL22797828 0.85 SCN9A (0.60) SCN9AGSK3AGSK3B
SCHEMBL22797825 0.85 SCN9A (0.60) SCN9AGSK3AGSK3B
SCHEMBL22797760 0.84 SCN9A (0.54) SCN9AMEN1KMT2ASMN1; SMN2LMNA
SCHEMBL2714887 0.82 IDH1 (0.49) GSK3AGSK3B
SCHEMBL20595156 0.81 SCN9A (0.60) SCN9AMEN1KMT2ASMN1; SMN2LMNA
SCHEMBL20595157 0.81 SCN9A (0.60) SCN9AMEN1KMT2ASMN1; SMN2LMNA
SCHEMBL2715979 0.81 ACACB (0.41) ACACB
SCHEMBL22809572 0.80 SCN9A (0.54) SCN9ABRAFKDRGSK3AGSK3B
SCHEMBL2714859 0.80 IDH1 (0.49) GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110612285-B Amide derivatives as Nav1.7 and Nav1.8 blockers 拉夸里亚创药株式会社 2023-04-04 — — CN claimed
EP-3487839-B1 AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS RAQUALIA PHARMA INC (JP) 2020-12-23 — — EP claimed
CN-110612285-A Amide derivatives as Nav1.7 and Nav1.8 blockers 拉夸里亚创药株式会社 2019-12-24 — — CN claimed
CN-110612285-B Amide derivatives as Nav1.7 and Nav1.8 blockers 拉夸里亚创药株式会社 2023-04-04 — — CN disclosed
US-11154544-B2 Amide derivatives as Nav1.7 and Nav1.8 blockers RAQUALIA PHARMA INC. (JP) 2021-10-26 — — US disclosed
US-11154544-B2 Amide derivatives as Nav1.7 and Nav1.8 blockers RAQUALIA PHARMA INC. (JP) 2021-10-26 — — US disclosed
EP-3487839-B1 AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS RAQUALIA PHARMA INC (JP) 2020-12-23 — — EP disclosed
EP-3487839-B1 AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS RAQUALIA PHARMA INC (JP) 2020-12-23 — — EP disclosed
CN-110612285-A Amide derivatives as Nav1.7 and Nav1.8 blockers 拉夸里亚创药株式会社 2019-12-24 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11154544-B2 Amide derivatives as Nav1.7 and Nav1.8 blockers SCN8A, SCN7A, SCN1A SCN9A 9/4885MEN1 3745/4885KMT2A 1799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.