Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279559 | 0.89 | JAK2 (0.38) | JAK2JAK1HTR1ADRD2HTR2A | |
| SCHEMBL2278884 | 0.88 | JAK2 (0.35) | JAK2JAK1FAAHHTR6MAPT | |
| SCHEMBL2272435 | 0.86 | JAK1 (0.43) | JAK1HTR1ADRD2HTR2AFAAH | |
| SCHEMBL2277557 | 0.84 | JAK1 (0.50) | JAK2JAK1TYK2JAK3HTR6 | |
| SCHEMBL2276023 | 0.81 | JAK1 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2283253 | 0.81 | JAK1 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2281787 | 0.80 | JAK1 (0.46) | JAK2JAK1TYK2JAK3HTR6 | |
| SCHEMBL2280657 | 0.80 | JAK2 (0.48) | JAK2JAK1TYK2JAK3HTR6 | |
| SCHEMBL2276746 | 0.80 | JAK2 (0.46) | JAK2JAK1TYK2JAK3HTR6 | |
| SCHEMBL2274417 | 0.80 | JAK1 (0.45) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |