Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SAT1 | P21673 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25727406 | 1.00 | MEN1 (0.33) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL22794786 | 0.98 | SAT1 (0.31) | MEN1KMT2ASAT1 | |
| SCHEMBL25700678 | 0.86 | PAOX (0.38) | MEN1KMT2AKDM4ELMNA | |
| SCHEMBL11608467 | 0.83 | BLM (0.43) | BLMPMP22HSD17B10KDM4E | |
| SCHEMBL22790826 | 0.82 | MEN1 (0.35) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL26280261 | 0.82 | MEN1 (0.35) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL8339207 | 0.82 | MEN1 (0.35) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL22856514 | 0.82 | — | — | |
| SCHEMBL23696569 | 0.82 | MEN1 (0.38) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL22906424 | 0.82 | MEN1 (0.38) | MEN1KMT2ABLMPMP22HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2021011634-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |
| WO-2020251969-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |