Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PKD1 | P98161 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29682671 | 1.00 | EGFR (0.69) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL28596406 | 0.93 | EGFR (0.81) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL29682936 | 0.93 | EGFR (0.81) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL28605782 | 0.92 | EGFR (0.69) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL29682659 | 0.92 | EGFR (0.69) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL28601690 | 0.92 | EGFR (0.68) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL28594066 | 0.91 | EGFR (0.68) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL29682802 | 0.91 | EGFR (0.64) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL28918852 | 0.91 | EGFR (0.64) | EGFRCHEK1AURKACCNT1JAK2 | |
| SCHEMBL22827036 | 0.89 | EGFR (0.86) | EGFRCHEK1AURKACCNT1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469713-B | Aryl phosphorus oxide derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116234556-A | Crystal form of aryl phosphorus oxide derivative free alkali and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-114644654-A | Oxidized aryl phosphorus derivative, acid salt or crystal form thereof, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-112469713-A | Aryl phosphorus oxide derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-03-09 | — | — | CN | disclosed |
| WO-2020253860-A1 | ARYL PHOSPHORUS OXIDE DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-12-24 | — | — | WO | disclosed |