Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280186 | 0.91 | JAK3 (0.58) | JAK3SYKPRKDCATRCYP2C9 | |
| SCHEMBL2275328 | 0.86 | SYK (0.64) | JAK3SYKCYP2C9NEK2JAK2 | |
| SCHEMBL2275732 | 0.82 | JAK3 (0.54) | JAK3SYKAXLJAK2JAK1 | |
| SCHEMBL1894044 | 0.81 | JAK3 (0.51) | JAK3SYKCYP2C9TYRO3NEK1 | |
| SCHEMBL1896786 | 0.81 | JAK3 (0.49) | JAK3SYKPRKDCATRCYP2C9 | |
| SCHEMBL2280877 | 0.81 | JAK3 (0.61) | JAK3SYKCYP2C9AXLSGK1 | |
| SCHEMBL2272592 | 0.81 | SYK (0.53) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2275295 | 0.81 | JAK3 (0.57) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2273646 | 0.81 | JAK3 (0.57) | JAK3SYKCYP2C9MAP4K4JAK2 | |
| SCHEMBL2278825 | 0.81 | JAK3 (0.60) | JAK3SYKCYP2C9AXLJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | claimed |