SCHEMBL22808973

SCHEMBL22808973

C[C@@H](C(=O)Nc1ccc(Cl)cc1)C1CCC(c2ccnc3cc(F)ccc23)CC1

nearest known ligand 0.86

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.86
CYP2C9 P11712 4/20 0.86
CYP2C8 P10632 3/20 0.86
TDO2 P48775 2/20 0.86
CYP3A4 P08684 1/20 0.86
KCNH2 Q12809 1/20 0.86
CHRNA1 P02708 1/20 0.58
CYP2C19 P33261 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18806699 1.00 IDO1 (0.86) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL18806701 1.00 IDO1 (0.86) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL17762851 1.00 IDO1 (0.86) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL18806700 1.00 IDO1 (0.86) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL18806674 0.94 IDO1 (0.76) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL18806676 0.94 IDO1 (0.76) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL17762852 0.94 IDO1 (0.76) IDO1CYP2C9CYP2C8TDO2CYP3A4
SCHEMBL18806675 0.94 IDO1 (0.76) IDO1CYP2C9CYP2C8TDO2CYP3A4
Linrodostat SCHEMBL20971679 0.93 IDO1 (1.00) IDO1CYP2C9CYP2C8TDO2CYP3A4
Linrodostat SCHEMBL21354182 0.93 IDO1 (1.00) IDO1CYP2C9CYP2C8TDO2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3215153-B1 IMMUNOREGULATORY AGENTS FLEXUS BIOSCIENCES INC (US) 2020-12-23 EP disclosed