Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 12/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595174 | 0.85 | SCN9A (0.51) | SCN9AMRGPRX4KMT2AMEN1MAPK1 | |
| SCHEMBL22798317 | 0.85 | SCN9A (0.61) | SCN9AMRGPRX4GPR52 | |
| SCHEMBL2714274 | 0.81 | SCN3A (0.56) | SCN9AMRGPRX4CYP3A4AAK1SCN3A | |
| SCHEMBL22809536 | 0.78 | SCN9A (0.47) | SCN9AMRGPRX4KMT2AMEN1MAPK1 | |
| SCHEMBL20595228 | 0.78 | SCN9A (0.54) | SCN9AMRGPRX4KMT2AMEN1MAPK1 | |
| SCHEMBL22797817 | 0.77 | SCN9A (0.49) | SCN9AMRGPRX4KMT2AMEN1MAPK1 | |
| SCHEMBL22798334 | 0.77 | SCN9A (0.53) | SCN9AMRGPRX4KMT2AMEN1KDM4E | |
| SCHEMBL20595197 | 0.76 | SCN9A (0.59) | SCN9AMRGPRX4GPR52 | |
| SCHEMBL22798235 | 0.76 | SCN9A (0.64) | SCN9AMRGPRX4MAPT | |
| SCHEMBL22798231 | 0.76 | SCN9A (0.52) | SCN9AMRGPRX4KMT2AKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |