Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809742 | 0.84 | SCN8A (0.53) | SCN8ASCN10APDE4BTSHR | |
| SCHEMBL955834 | 0.82 | SCN8A (0.48) | SCN8ASCN10APTGER1CSNK1DPTGDR2 | |
| SCHEMBL955835 | 0.82 | SCN8A (0.48) | SCN8ASCN10APTGER1CSNK1DPTGDR2 | |
| SCHEMBL955295 | 0.79 | SCN8A (0.48) | SCN8ASCN10APTGER1CSNK1DPTGDR2 | |
| SCHEMBL955296 | 0.79 | SCN8A (0.48) | SCN8ASCN10APTGER1CSNK1DPTGDR2 | |
| SCHEMBL18570608 | 0.79 | SCN8A (0.50) | SCN8ASCN10APTGDR2POLBMAPT | |
| SCHEMBL21722870 | 0.78 | APP (0.46) | PTGDR2POLBMAPT | |
| SCHEMBL22809712 | 0.78 | SCN8A (0.47) | SCN8ASCN10ACSNK1DPTGDR2MGLL | |
| SCHEMBL20912029 | 0.78 | SRC (0.45) | PTGER1PTGDR2SRCPOLB | |
| SCHEMBL18570882 | 0.77 | SCN8A (0.46) | SCN8ASCN10APTGDR2MGLLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |