Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154516 | 0.86 | KMT2A (0.50) | TSHRPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL21159015 | 0.83 | MAPT (0.49) | TSHRCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL20148744 | 0.83 | CYP2D6 (0.47) | TSHRCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL20153278 | 0.82 | NPC1 (0.54) | TSHRMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL20626520 | 0.81 | MAPT (0.43) | TSHRCYP1A2CYP3A4CYP2D6POLB | |
| SCHEMBL20365006 | 0.76 | TSHR (0.55) | TSHRCYP1A2CYP3A4CYP2D6POLB | |
| SCHEMBL21540450 | 0.75 | MAPT (0.53) | TSHRCYP1A2CYP3A4CYP2D6POLB | |
| SCHEMBL20153188 | 0.74 | RET (0.47) | SMN1; SMN2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1000444 | 0.73 | MAPT (0.64) | TSHRCYP1A2CYP3A4CYP2D6POLB | |
| SCHEMBL16980489 | 0.72 | MAPT (0.50) | TSHRCYP1A2CYP3A4CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |