Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 6/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19273272 | 0.89 | CHRM4 (0.53) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL18429047 | 0.88 | CHRM4 (0.49) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL18429055 | 0.88 | CHRM4 (0.49) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813523 | 0.87 | CHRM4 (0.57) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813426 | 0.86 | CHRM4 (0.49) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813682 | 0.86 | CHRM4 (0.51) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813405 | 0.85 | CHRM4 (0.56) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813681 | 0.85 | CHRM4 (0.52) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL22813689 | 0.82 | CHRM4 (0.50) | CHRM4CHRM2CHRM1TP53TDP1 | |
| SCHEMBL18429049 | 0.82 | CHRM4 (0.53) | CHRM4CHRM2CHRM1TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822262-A1 | MUSCARINIC AGONISTS | Heptares Therapeutics Limited (GB) | 2021-05-19 | — | — | EP | disclosed |
| EP-3331869-B1 | MUSCARINIC AGONISTS | HEPTARES THERAPEUTICS LTD (GB) | 2020-12-23 | — | — | EP | disclosed |