Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22816295 | 0.90 | CYP19A1 (0.77) | CYP19A1GABRA2GABRB2ALDH1A1MAPT | |
| SCHEMBL22815805 | 0.88 | CYP19A1 (0.74) | CYP19A1GABRA2GABRB2ALDH1A1MAPT | |
| SCHEMBL22816671 | 0.88 | CYP19A1 (0.61) | CYP19A1GABRA2GABRB2ALDH1A1MAPT | |
| SCHEMBL22816677 | 0.88 | CYP19A1 (0.64) | CYP19A1GABRA2GABRB2ALDH1A1MAPT | |
| SCHEMBL22816020 | 0.87 | CYP19A1 (0.53) | CYP19A1GABRA2GABRB2ALDH1A1MAPT | |
| SCHEMBL22815756 | 0.84 | CYP19A1 (0.49) | CYP19A1GABRA2GABRB2MAPTKDM4E | |
| SCHEMBL22815695 | 0.84 | CYP19A1 (0.50) | CYP19A1GABRA2GABRB2MAPTKDM4E | |
| SCHEMBL22816870 | 0.84 | CYP19A1 (0.60) | CYP19A1ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL22815952 | 0.83 | CYP19A1 (0.57) | CYP19A1ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL22815867 | 0.83 | CYP19A1 (0.52) | CYP19A1GABRA2GABRB2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |