Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 4/20 | 0.60 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24842903 | 0.92 | ESR2 (0.65) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL29733605 | 0.89 | ESR2 (0.58) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL22821061 | 0.89 | ESR2 (0.58) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL22821052 | 0.88 | ESR2 (0.57) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL24842639 | 0.87 | NR1H2 (0.61) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL22821173 | 0.87 | ESR2 (0.56) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL22820951 | 0.85 | ESR2 (0.54) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL24843624 | 0.82 | ESR2 (0.51) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL22821171 | 0.82 | ESR2 (0.63) | ESR2NR1H2NAMPTUCHL1ABHD6 | |
| SCHEMBL25407478 | 0.81 | ESR2 (0.60) | ESR2NR1H2NAMPTUCHL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257549-A2 | COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX, INC. (US) | 2020-12-24 | — | — | WO | disclosed |