Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | SKP1 | P63208 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29517976 | 1.00 | SYK (0.53) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL14196275 | 1.00 | SYK (0.53) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL22454875 | 0.94 | MAP4K4 (0.60) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL29518215 | 0.94 | MAP4K4 (0.60) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL28667375 | 0.94 | MAP4K4 (0.60) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL29518126 | 0.93 | CKS1B (0.60) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL28666722 | 0.93 | CKS1B (0.60) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL14196277 | 0.89 | PDE10A (0.48) | PDE10A | |
| SCHEMBL529863 | 0.88 | MAP4K4 (0.58) | SYKCKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL594137 | 0.88 | MAP4K4 (0.58) | SYKCKS1BSKP1SKP2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020253762-A1 | INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2020-12-24 | — | — | WO | disclosed |