Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCND3 | P30281 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | CD69 | Q07108 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | BRD2 | P25440 | 2/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22807426 | 0.83 | SRC (0.68) | BTKJAK3CD69FLT3MAP3K7 | |
| SCHEMBL22807398 | 0.82 | IRAK4 (0.60) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL22807405 | 0.78 | BRD4 (0.59) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL29549396 | 0.77 | CCND3 (0.63) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL22807437 | 0.77 | EGFR (0.65) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL22828249 | 0.77 | CCNK (0.63) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL22807421 | 0.77 | CCND3 (0.63) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL29549413 | 0.77 | EGFR (0.65) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL22807397 | 0.75 | BTK (0.62) | BTKJAK3CD69ADRA2AFLT3 | |
| SCHEMBL22828273 | 0.75 | CCNK (0.60) | CCNKCCNA2CDK2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257385-A1 | SMALL MOLECULE INHIBITORS OF SRC TYROSINE KINASE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-24 | — | — | WO | disclosed |