Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26241332 | 0.90 | CA12 (0.46) | TLR8TLR7CA12CA9ADORA2A | |
| Hydrochloric Acid SCHEMBL1234320 | 0.86 | TLR7 (0.46) | TLR8TLR7ADORA2ALMNAPOLB | |
| SCHEMBL22790568 | 0.84 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL1233348 | 0.82 | TLR7 (0.50) | TLR8TLR7ADORA2ALMNAPOLB | |
| SCHEMBL1233729 | 0.81 | TLR7 (0.47) | TLR8TLR7ADORA2AADORA3ADORA1 | |
| Hydrochloric Acid SCHEMBL1233596 | 0.81 | TLR8 (0.44) | TLR8TLR7ADORA2ALMNAPOLB | |
| SCHEMBL1233649 | 0.79 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL1233451 | 0.79 | TLR7 (0.51) | TLR8TLR7ADORA2ALMNAPOLB | |
| SCHEMBL1233266 | 0.79 | TLR7 (0.44) | TLR8TLR7ADORA2ALMNAPOLB | |
| SCHEMBL1234353 | 0.78 | TLR7 (0.55) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257235-A1 | 1-(4-(AMINOMETHYL)BENZYL)-2-BUTYL-2H-PYRAZOLO[3,4-C]QUINOLIN-4-AMINE DERIVATIVES AND RELATED COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR) 7/8 AGONISTS, AS WELL AS ANTIBODY DRUG CONJUGATES THEREOF FOR USE IN CANCER THERAPY AND DIAGNOSIS | SUTRO BIOPHARMA, INC. (US) | 2020-12-24 | — | — | WO | disclosed |