Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 1.00 |
| ▸ | TNKS | O95271 | 3/20 | 0.85 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22829772 | 0.94 | PARP1 (0.94) | PARP1TNKSTNKS2 | |
| SCHEMBL22829832 | 0.94 | PARP1 (1.00) | PARP1TNKSTNKS2 | |
| SCHEMBL22829783 | 0.92 | PARP1 (1.00) | PARP1TNKSTNKS2 | |
| SCHEMBL22829834 | 0.92 | PARP1 (1.00) | PARP1TNKSTNKS2 | |
| SCHEMBL2474012 | 0.91 | PARP1 (0.89) | PARP1TNKSTNKS2 | |
| SCHEMBL30293105 | 0.91 | PARP1 (0.89) | PARP1TNKSTNKS2 | |
| SCHEMBL22829810 | 0.90 | PARP1 (1.00) | PARP1TNKSTNKS2 | |
| SCHEMBL15846129 | 0.88 | PARP1 (0.79) | PARP1TNKSTNKS2 | |
| SCHEMBL15204765 | 0.88 | PARP1 (0.85) | PARP1TNKSTNKS2 | |
| SCHEMBL22829776 | 0.88 | PARP1 (1.00) | PARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542282-B2 | Low affinity poly(AD-ribose) polymerase 1 dependent cytotoxic agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-01-03 | — | — | US | disclosed |
| US-20200407374-A1 | LOW AFFINITY POLY(AD-RIBOSE) POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11542282-B2 | Low affinity poly(AD-ribose) polymerase 1 dependent cytotoxic agents | PARP1, PARP11, PARP2 | PARP1 1/4885TNKS 54/4885TNKS2 101/4885 |
| US-20200407374-A1 | LOW AFFINITY POLY(AD-RIBOSE) POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS | PARP1, PARP11, PARP2 | PARP1 1/4885TNKS 54/4885TNKS2 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.