⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22832581 | 0.81 | — | — | |
| SCHEMBL22832565 | 0.79 | — | — | |
| SCHEMBL30959644 | 0.67 | — | — | |
| SCHEMBL22845138 | 0.66 | — | — | |
| SCHEMBL23116638 | 0.66 | — | — | |
| SCHEMBL23139133 | 0.66 | — | — | |
| SCHEMBL22917991 | 0.65 | — | — | |
| SCHEMBL22845217 | 0.65 | — | — | |
| SCHEMBL10076729 | 0.65 | — | — | |
| SCHEMBL22832602 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542270-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-11542270-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2023-01-03 | — | — | US | disclosed |
| EP-3990461-A1 | THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID COMPOUNDS HAVING BCKDK INHIBITING ACTIVITY | Pfizer Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| US-11059833-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-11059833-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20210087204-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-03-25 | — | — | US | disclosed |
| US-20210087204-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-03-25 | — | — | US | disclosed |
| US-20210024536-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-01-28 | — | — | US | disclosed |
| US-20210024536-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-01-28 | — | — | US | disclosed |
| WO-2020261205-A1 | THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID COMPOUNDS HAVING BCKDK INHIBITING ACTIVITY | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020261205-A1 | THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID COMPOUNDS HAVING BCKDK INHIBITING ACTIVITY | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |