Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.60 |
| ▸ | EGLN2 | Q96KS0 | 13/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 13/20 | 0.60 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17641374 | 0.90 | EGLN1 (0.75) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL22838485 | 0.89 | EGLN1 (0.64) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL22838470 | 0.88 | EGLN1 (0.55) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL17643194 | 0.88 | EGLN1 (0.71) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL22838408 | 0.87 | EGLN1 (0.62) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL22838670 | 0.84 | EGLN1 (0.59) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL17629628 | 0.83 | EGLN1 (0.80) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633113 | 0.81 | EGLN1 (0.79) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL22838662 | 0.81 | EGLN1 (0.80) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL22838500 | 0.81 | EGLN1 (0.67) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-12-30 | — | — | EP | disclosed |