Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 9/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 7/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22838551 | 0.81 | EGLN1 (0.41) | EGLN1EGLN3EGLN2 | |
| SCHEMBL22838468 | 0.77 | EGLN1 (0.57) | EGLN1EGLN3EGLN2 | |
| SCHEMBL17641302 | 0.73 | EGLN1 (0.47) | EGLN1EGLN3EGLN2 | |
| SCHEMBL1960754 | 0.67 | EGLN1 (0.71) | EGLN1EGLN3EGLN2 | |
| SCHEMBL16839206 | 0.66 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL16839156 | 0.65 | EGLN1 (0.61) | EGLN1 | |
| SCHEMBL1960755 | 0.65 | EGLN1 (0.64) | EGLN1EGLN3EGLN2 | |
| SCHEMBL16839201 | 0.65 | EGLN1 (0.56) | EGLN1 | |
| SCHEMBL16839199 | 0.65 | HCRTR1 (0.43) | EGLN1 | |
| SCHEMBL24257508 | 0.64 | EGLN1 (0.49) | EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-12-30 | — | — | EP | disclosed |