Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274554 | 1.00 | TDP1 (0.44) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL19519807 | 0.89 | TDP1 (0.44) | TDP1ITGB3ITGA2BATMCPB2 | |
| SCHEMBL563755 | 0.86 | FOLH1 (0.50) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL18786391 | 0.86 | FOLH1 (0.47) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL30947360 | 0.86 | FOLH1 (0.50) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL23504916 | 0.86 | FOLH1 (0.50) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL14079858 | 0.86 | FOLH1 (0.50) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL21235689 | 0.86 | FOLH1 (0.43) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL563754 | 0.86 | FOLH1 (0.50) | TDP1FOLH1ITGB3ITGA2BATM | |
| SCHEMBL22878289 | 0.83 | FOLH1 (0.47) | TDP1FOLH1ITGB3ITGA2BATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3335736-B1 | HETERODIMERS OF GLUTAMIC ACID | MOLECULAR INSIGHT PHARM INC (US) | 2020-12-30 | — | — | EP | disclosed |