Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 15/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756541 | 0.87 | FGFR4 (0.40) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21386612 | 0.85 | FGFR1 (0.57) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756512 | 0.84 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756543 | 0.83 | FGFR4 (0.37) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756586 | 0.79 | FGFR4 (0.38) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL22840828 | 0.78 | JAK2 (0.37) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21756566 | 0.77 | FGFR4 (0.59) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756514 | 0.75 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756498 | 0.74 | FGFR1 (0.57) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21756587 | 0.72 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543227-B1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2020-12-30 | — | — | EP | disclosed |