Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.52 |
| ▸ | CTSD | P07339 | 7/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283475 | 0.94 | BACE1 (0.55) | BACE1CTSDTNIK | |
| SCHEMBL2283355 | 0.90 | BACE1 (0.46) | BACE1CTSDDHODHTNIK | |
| SCHEMBL2279474 | 0.88 | BACE1 (0.50) | BACE1CTSD | |
| SCHEMBL2281928 | 0.88 | BACE1 (0.69) | BACE1CTSDKCNH2TNIK | |
| SCHEMBL2284002 | 0.87 | BACE1 (0.47) | BACE1CTSDKCNH2 | |
| SCHEMBL2284060 | 0.86 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2283445 | 0.86 | BACE1 (0.51) | BACE1CTSDTNIK | |
| Ammonia Solution, Strong SCHEMBL13685453 | 0.85 | BACE1 (0.55) | BACE1CTSDDHODHKCNH2KDM1A | |
| SCHEMBL2279579 | 0.85 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2277204 | 0.84 | BACE1 (0.49) | BACE1CTSDTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | BACE2, BACE1, PSEN2 | BACE1 2/4885CTSD 721/4885DHODH 2124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.