Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.63 |
| ▸ | CTSD | P07339 | 13/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864975 | 0.95 | BACE1 (0.69) | BACE1CTSDADORA2AADORA1 | |
| Formic Acid SCHEMBL2280977 | 0.92 | BACE1 (0.62) | BACE1CTSD | |
| Formic Acid SCHEMBL2286466 | 0.90 | BACE1 (0.54) | BACE1CTSD | |
| Formic Acid SCHEMBL2285183 | 0.89 | BACE1 (0.53) | BACE1CTSD | |
| Formic Acid SCHEMBL2286944 | 0.87 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL7864615 | 0.87 | BACE1 (0.68) | BACE1CTSD | |
| Formic Acid SCHEMBL2279471 | 0.86 | BACE1 (0.65) | BACE1CTSDADORA2AADORA1 | |
| Formic Acid SCHEMBL2278980 | 0.86 | BACE1 (0.56) | BACE1CTSD | |
| Formic Acid SCHEMBL2282027 | 0.86 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL2281795 | 0.85 | BACE1 (0.58) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | BACE2, BACE1, PSEN2 | BACE1 2/4885CTSD 721/4885ADORA2A 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.