Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9989430 | 0.88 | TMEM97 (0.64) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL9989426 | 0.88 | TMEM97 (0.64) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL20129285 | 0.84 | CRBN (0.62) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL23418195 | 0.84 | DDB1 (0.49) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL845412 | 0.83 | CRBN (0.55) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL27552579 | 0.81 | DDB1 (0.59) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL23418187 | 0.77 | DDB1 (0.53) | CRBNDDB1TMEM97HTR2BHTR3E | |
| SCHEMBL6178641 | 0.76 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29922280 | 0.76 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2049711 | 0.76 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |