Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 17/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 17/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9988737 | 0.85 | DDB1 (0.64) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL22845577 | 0.85 | DDB1 (0.67) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL845434 | 0.84 | CRBN (0.57) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL21070336 | 0.84 | DDB1 (0.65) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL22845277 | 0.84 | DDB1 (0.52) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL22845482 | 0.84 | DDB1 (0.49) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18270945 | 0.82 | DDB1 (0.65) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18263931 | 0.82 | DDB1 (0.63) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18270883 | 0.82 | DDB1 (0.63) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL19585360 | 0.81 | DDB1 (0.64) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |