Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.80 |
| ▸ | STS | P08842 | 8/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 3/20 | 1.00 |
| ▸ | ABCC1 | P33527 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.90 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | CA1 | P00915 | 2/20 | 0.80 |
| ▸ | CA2 | P00918 | 2/20 | 0.80 |
| ▸ | CA9 | Q16790 | 2/20 | 0.80 |
| ▸ | CA4 | P22748 | 1/20 | 0.80 |
| ▸ | CA6 | P23280 | 1/20 | 0.80 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone Sulfuric Acid SCHEMBL12920398 | 1.00 | STS (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL6530673 | 1.00 | STS (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL14375453 | 1.00 | STS (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL29369653 | 1.00 | STS (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL29769589 | 0.99 | STS (0.98) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL22551312 | 0.99 | STS (0.98) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL29379988 | 0.99 | STS (0.98) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL21577 | 0.95 | CYP3A4 (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL4443808 | 0.95 | CYP3A4 (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 | |
| Estrone Sulfuric Acid SCHEMBL6556684 | 0.95 | CYP3A4 (1.00) | STSABCC4ABCC1CYP2C9SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3730 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594237-B2 | Mucoadhesive gel composition | Viramal Limited (GB) | 2026-04-07 | — | — | US | claimed |
| EP-4705304-A1 | AMIDO PYRIDO[3,4-B]INDOLE-1, 4-DIONE COMPOUNDS FOR TREATMENT OF PORPHYRIAS | Portal Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260063649-A1 | PROCESS FOR DETERMINING PREGNANCY AND/OR A PREGNANCY STAGE OF AN UNGULATE FROM ITS FECES | UNIV LIEGE (BE) | 2026-03-05 | — | — | US | claimed |
| US-20260049082-A1 | AMIDO PYRIDO[3,4-B]INDOLE-1,4-DIONE COMPOUNDS FOR TREATMENT OF PORPHYRIAS | PORTAL THERAPEUTICS INC (US) | 2026-02-19 | — | — | US | claimed |
| EP-4692783-A1 | BIOMARKER AND SYSTEM FOR PREDICTING EVOLUTION INTO ACLF OR DEATH OF ACLF PATIENT, AND USES THEREOF | Shanghai Ganning Medical and Technology Co., Ltd (CN) | 2026-02-11 | — | — | EP | claimed |
| US-20250387389-A1 | METHODS OF TREATING DISEASE WITH LEVOKETOCONAZOLE | XERIS PHARMACEUTICALS, INC. (US) | 2025-12-25 | — | — | US | claimed |
| US-12377096-B2 | Methods of treating disease with levoketoconazole | XERIS PHARMACEUTICALS, INC. (US) | 2025-08-05 | — | — | US | claimed |
| US-12370237-B2 | Lipopeptides for use in treating liver diseases and cardiovascular diseases | RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG (DE) | 2025-07-29 | — | — | US | claimed |
| CN-119510604-A | Biomarker for predicting whether ACLF patient will die, system and application thereof | 上海甘宁医疗科技有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119470683-A | Biomarker for predicting whether ACLF will be formed, system and application thereof | 上海甘宁医疗科技有限公司 | 2025-02-18 | — | — | CN | claimed |
| US-4716109-A | ENZYME INHIBITOR LABEL | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1987-12-29 | — | — | US | claimed |
| EP-0247730-A2 | Antibodies, their preparation and use and products containing them | Antibody Technology Limited (GB) | 1987-12-02 | — | — | EP | claimed |
| US-4629449-A | Vaginal dispenser for dispensing beneficial hormone | ALZA CORPORATION (US) | 1986-12-16 | — | — | US | claimed |
| US-4628051-A | LOW DOSAGE OF ESTROGEN AND PROGESTOGEN | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-09 | — | — | US | claimed |
| US-4587212-A | Immunoassay | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1986-05-06 | — | — | US | claimed |
| EP-0095286-B1 | IMMUNOASSAY | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1985-12-18 | — | — | EP | claimed |
| EP-0117648-A2 | Immunoassay | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1984-09-05 | — | — | EP | claimed |
| EP-0095286-A1 | Immunoassay | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1983-11-30 | — | — | EP | claimed |
| US-4402695-A | Device for delivering agent in vagina | ALZA CORPORATION (US) | 1983-09-06 | — | — | US | claimed |
| US-4294922-A | Method for monitoring pregnancy in milk-producing domestic animals | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1981-10-13 | — | — | US | claimed |