SCHEMBL22848719

SCHEMBL22848719

COc1cc2nn([C@H]3CC[C@H](C(C)C)CC3)cc2cc1NC(=O)c1cccc(C)n1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 20/20 0.64
FLT3 P36888 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24607614 0.93 IRAK4 (0.62) IRAK4FLT3
SCHEMBL26355095 0.90 IRAK4 (0.67) IRAK4FLT3
SCHEMBL28767613 0.90 IRAK4 (0.69) IRAK4FLT3
SCHEMBL25904806 0.89 IRAK4 (0.68) IRAK4FLT3
SCHEMBL22848626 0.89 IRAK4 (0.68) IRAK4FLT3
SCHEMBL24606922 0.89 IRAK4 (0.81) IRAK4FLT3
SCHEMBL22835751 0.89 IRAK4 (0.65) IRAK4FLT3
SCHEMBL25904748 0.89 IRAK4 (0.65) IRAK4FLT3
SCHEMBL26346751 0.89 IRAK4 (0.62) IRAK4
SCHEMBL22906398 0.88 IRAK4 (0.79) IRAK4FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 US disclosed
WO-2020264499-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-12-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 IRAK4 4/4885FLT3 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.