Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.62 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22849918 | 0.93 | CRBN (0.64) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22848988 | 0.91 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26372292 | 0.91 | DDB1 (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21855328 | 0.90 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19436909 | 0.90 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL23484688 | 0.90 | DDB1 (0.63) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21997825 | 0.89 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21069257 | 0.89 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21070727 | 0.89 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21069840 | 0.89 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-11639343-B2 | Compounds targeting and degrading BCR-ABL protein and its antitumor application | SHANGHAITECH UNIVERSITY (CN) | 2023-05-02 | — | — | US | disclosed |
| US-11639343-B2 | Compounds targeting and degrading BCR-ABL protein and its antitumor application | SHANGHAITECH UNIVERSITY (CN) | 2023-05-02 | — | — | US | disclosed |
| US-20200407342-A1 | COMPOUNDS TARGETING AND DEGRADING BCR-ABL PROTEIN AND ITS ANTITUMOR APPLICATION | SHANGHAITECH UNIVERSITY (CN) | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | CRBN 65/4885DDB1 395/4885IKZF3 282/4885 |
| US-20200407342-A1 | COMPOUNDS TARGETING AND DEGRADING BCR-ABL PROTEIN AND ITS ANTITUMOR APPLICATION | CRBN, VHL, CBL | CRBN 1/4885DDB1 478/4885IKZF3 1017/4885 |
| US-11639343-B2 | Compounds targeting and degrading BCR-ABL protein and its antitumor application | CRBN, VHL, CBL | CRBN 1/4885DDB1 478/4885IKZF3 1017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.