Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416921 | 0.87 | DYRK1A (1.00) | DYRK1AKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL16918346 | 0.76 | DYRK1A (0.60) | DYRK1AKDM4EDAONAPRTTTR | |
| SCHEMBL25023618 | 0.74 | DYRK1A (0.69) | DYRK1AKDM4EDAOGAAF7 | |
| Hydrochloric Acid SCHEMBL17597584 | 0.74 | DYRK1A (0.58) | DYRK1AKDM4EDAONAPRTTTR | |
| SCHEMBL11171235 | 0.74 | MCL1 (0.56) | DYRK1AKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL11166619 | 0.74 | AKR1C2 (0.54) | DYRK1AKDM4EDAONAPRTPOLB | |
| SCHEMBL11161805 | 0.74 | MCL1 (0.57) | DYRK1AKDM4ENAPRTTTRGAA | |
| SCHEMBL10901104 | 0.74 | DYRK1A (0.58) | DYRK1AKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL396923 | 0.71 | AURKA (0.58) | DYRK1AKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL11164633 | 0.71 | DYRK1A (0.64) | DYRK1AKDM4EPRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |