Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22852605 | 0.93 | HRH3 (0.39) | NPC1HRH3SMN1; SMN2KDM4E | |
| SCHEMBL24829687 | 0.79 | NPC1 (0.44) | NPC1HRH3SMN1; SMN2CYP2D6 | |
| SCHEMBL21733034 | 0.78 | SMN1; SMN2 (0.41) | NPC1HRH3SMN1; SMN2CYP2D6KDM4E | |
| SCHEMBL24661412 | 0.78 | SMN1; SMN2 (0.41) | NPC1HRH3SMN1; SMN2HSD11B1 | |
| SCHEMBL17285631 | 0.77 | HRH3 (0.41) | NPC1HRH3SMN1; SMN2HSD11B1 | |
| SCHEMBL24661764 | 0.76 | HRH3 (0.40) | HRH3SMN1; SMN2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL24661763 | 0.76 | HRH3 (0.40) | HRH3SMN1; SMN2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL22852603 | 0.75 | NPC1 (0.37) | NPC1 | |
| SCHEMBL24829688 | 0.75 | HRH3 (0.38) | NPC1HRH3 | |
| SCHEMBL22852678 | 0.74 | NPC1 (0.34) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200407374-A1 | LOW AFFINITY POLY(AD-RIBOSE) POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200407374-A1 | LOW AFFINITY POLY(AD-RIBOSE) POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS | PARP1, PARP11, PARP2 | NPC1 837/4885HRH3 4562/4885SMN1; SMN2 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.