Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294599 | 1.00 | MAP2K2 (0.43) | MAP2K2MAP2K1SMN1; SMN2TDP1POLB | |
| SCHEMBL22853359 | 0.87 | KDM4E (0.42) | MAP2K2MAP2K1SMN1; SMN2TDP1POLB | |
| SCHEMBL30294715 | 0.87 | KDM4E (0.42) | MAP2K2MAP2K1SMN1; SMN2TDP1POLB | |
| SCHEMBL30294254 | 0.84 | CLCN2 (0.46) | — | |
| SCHEMBL22853007 | 0.84 | CLCN2 (0.46) | — | |
| SCHEMBL22853027 | 0.81 | RECQL (0.42) | SMN1; SMN2POLBKDM4ELMNACYP1A2 | |
| SCHEMBL30294633 | 0.81 | RECQL (0.42) | SMN1; SMN2POLBKDM4ELMNACYP1A2 | |
| SCHEMBL22853053 | 0.81 | MRGPRX4 (0.42) | SMN1; SMN2TDP1POLBKDM4ELMNA | |
| SCHEMBL30294656 | 0.81 | MRGPRX4 (0.42) | SMN1; SMN2TDP1POLBKDM4ELMNA | |
| SCHEMBL24553052 | 0.77 | MAPT (0.42) | SMN1; SMN2TDP1KDM4ELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |