Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18789241 | 0.83 | RET (0.55) | RETAURKAAURKBSYK | |
| SCHEMBL30401442 | 0.83 | RET (0.55) | RETAURKAAURKBSYK | |
| SCHEMBL18789278 | 0.83 | RET (0.55) | RETAURKAAURKBSYK | |
| SCHEMBL18789231 | 0.80 | RET (0.55) | RETAURKAAURKBRIPK1 | |
| SCHEMBL19813620 | 0.79 | RET (0.51) | RETAURKAAURKBSYK | |
| SCHEMBL19823168 | 0.79 | RET (0.51) | RETAURKAAURKBSYK | |
| SCHEMBL19813413 | 0.76 | RET (0.51) | RETAURKAAURKBRIPK1 | |
| SCHEMBL19349943 | 0.73 | RET (0.46) | RETAURKAAURKBRIPK1SYK | |
| SCHEMBL29969423 | 0.73 | RET (0.54) | RETAURKAAURKBRIPK1SYK | |
| SCHEMBL21744575 | 0.72 | KDM4E (0.66) | RETAURKAAURKBRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200407341-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200407341-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | RET 1/4885AURKA 1749/4885AURKB 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.