Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.56 |
| ▸ | JAK1 | P23458 | 20/20 | 0.56 |
| ▸ | TYK2 | P29597 | 20/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | STAT1 | P42224 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855943 | 1.00 | JAK2 (0.56) | JAK2JAK1TYK2JAK3KDR | |
| Hydrochloric Acid SCHEMBL31707386 | 0.99 | JAK2 (0.55) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22855940 | 0.85 | JAK2 (0.67) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22855945 | 0.85 | JAK1 (0.69) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22855944 | 0.85 | JAK1 (0.69) | JAK2JAK1TYK2JAK3KDR | |
| Hydrochloric Acid SCHEMBL31707387 | 0.84 | JAK1 (0.68) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22856006 | 0.84 | JAK2 (0.56) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22855939 | 0.82 | JAK2 (0.71) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22856008 | 0.82 | JAK2 (0.71) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL22856256 | 0.81 | JAK2 (0.55) | JAK2JAK1TYK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020259584-A1 | HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY | GUANGZHOU INNOCARE PHARMA TECH CO., LTD. (CN) | 2020-12-30 | — | — | WO | disclosed |