Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069676 | 0.87 | TSHR (0.52) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL20147939 | 0.84 | TSHR (0.49) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL22857092 | 0.80 | RET (0.40) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL21640977 | 0.72 | TSHR (0.47) | ALDH1A1TSHRSMN1; SMN2USP2LMNA | |
| SCHEMBL3154658 | 0.70 | USP2 (0.70) | KDM4EALDH1A1PKMSMN1; SMN2USP2 | |
| SCHEMBL26789169 | 0.70 | USP2 (0.70) | KDM4EALDH1A1PKMSMN1; SMN2USP2 | |
| SCHEMBL26789172 | 0.70 | USP2 (0.70) | KDM4EALDH1A1PKMSMN1; SMN2USP2 | |
| SCHEMBL12409354 | 0.69 | SMN1; SMN2 (0.64) | PKMSMN1; SMN2USP2LMNATP53 | |
| SCHEMBL1101625 | 0.69 | SMN1; SMN2 (0.64) | PKMSMN1; SMN2USP2LMNATP53 | |
| SCHEMBL12409226 | 0.69 | SMN1; SMN2 (0.64) | PKMSMN1; SMN2USP2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | KDM4E 547/4885ALDH1A1 2547/4885TSHR 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.