Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147984 | 0.88 | RET (0.36) | RETSMN1; SMN2TP53ALDH1A1KDM5A | |
| SCHEMBL20070059 | 0.83 | SMN1; SMN2 (0.38) | RETSMN1; SMN2TP53ALDH1A1CCNA2 | |
| SCHEMBL20147533 | 0.82 | RET (0.37) | RETSMN1; SMN2TP53ALDH1A1KDM5A | |
| SCHEMBL25444710 | 0.80 | KDM5A (0.46) | SMN1; SMN2TP53ALDH1A1CCNA2CDK2 | |
| SCHEMBL25122039 | 0.80 | KDM5A (0.46) | SMN1; SMN2TP53ALDH1A1CCNA2CDK2 | |
| SCHEMBL25122038 | 0.76 | EPHX1 (0.48) | SMN1; SMN2TP53CCNA2CDK2CCNA1 | |
| SCHEMBL20070140 | 0.75 | SMN1; SMN2 (0.37) | RETSMN1; SMN2TP53ALDH1A1KDM5A | |
| SCHEMBL20147507 | 0.74 | RET (0.35) | RETSMN1; SMN2TP53ALDH1A1KDM5A | |
| SCHEMBL20147955 | 0.71 | TP53 (0.44) | RETSMN1; SMN2TP53ALDH1A1CCNA2 | |
| SCHEMBL21344393 | 0.70 | ACKR3 (0.35) | SMN1; SMN2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | RET 1/4885SMN1; SMN2 646/4885TP53 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.