Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070277 | 0.91 | RET (0.51) | RETGPR119SETD7MAP4K4 | |
| SCHEMBL25504585 | 0.90 | RET (0.51) | RETGPR119SETD7 | |
| SCHEMBL20148021 | 0.82 | RET (0.45) | RET | |
| SCHEMBL20158745 | 0.82 | RET (0.50) | RETGPR119SETD7 | |
| SCHEMBL21652002 | 0.82 | RET (0.50) | RETGPR119 | |
| SCHEMBL20147320 | 0.81 | SETD7 (0.36) | RETGPR119SETD7MAP4K4 | |
| SCHEMBL20205851 | 0.80 | RET (0.47) | RET | |
| SCHEMBL20205793 | 0.80 | RET (0.50) | RET | |
| SCHEMBL20147491 | 0.77 | RET (0.51) | RETGPR119SETD7MAP4K4 | |
| SCHEMBL20148023 | 0.75 | RET (0.45) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | RET 1/4885GPR119 1905/4885SETD7 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.