Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 19/20 | 0.84 |
| ▸ | NSD2 | O96028 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | BID | P55957 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | ASPH | Q12797 | 1/20 | 0.64 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.64 |
| ▸ | BAD | Q92934 | 1/20 | 0.64 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.64 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573180 | 1.00 | BCL2 (0.84) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL21573219 | 0.97 | BCL2 (0.83) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL21573204 | 0.93 | BCL2 (0.76) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL22562908 | 0.93 | BCL2 (0.72) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL19853638 | 0.93 | BCL2 (0.83) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL19853631 | 0.92 | BCL2 (0.83) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL24982906 | 0.91 | BCL2 (0.84) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL20580489 | 0.91 | BCL2 (1.00) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL20580574 | 0.91 | BCL2 (1.00) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL23489329 | 0.91 | BCL2 (0.84) | BCL2NSD2ADORA3CYP2C9ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672639-B1 | COMBINATION PRODUCT OF A BCL-2 INHIBITOR AND IBRUTINIB FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| EP-3672594-B1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| WO-2021018240-A1 | COMBINATION PRODUCT OF A BCL-2/BCL-XL INHIBITOR AND A CHEMOTHERAPEUTIC AGENT AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-02-04 | — | — | WO | disclosed |
| WO-2021000899-A1 | A PHARMACEUTICAL COMBINATION CONTAINING mTOR INHIBITOR AND USE THEREOF | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-01-07 | — | — | WO | disclosed |