SCHEMBL22858663

CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCC(C(O)O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1

nearest known ligand 0.88

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	BCL2L1	Q07817	18/20	0.88

▸	BCL2	P10415	15/20	0.88

▸	BAD	Q92934	4/20	0.88

▸	BCL2L2	Q92843	2/20	0.88

▸	BCL2L11	O43521	1/20	0.88

▸	CYP2C9	P11712	1/20	0.88

▸	MCL1	Q07820	1/20	0.88

▸	ASPH	Q12797	1/20	0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL15872861	0.95	BCL2L1 (0.89)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL15872859	0.95	BCL2L1 (0.89)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19503523	0.94	BCL2L1 (0.92)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145093	0.94	BCL2L1 (0.93)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145101	0.94	BCL2L1 (0.93)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145160	0.94	BCL2L1 (0.85)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145161	0.94	BCL2L1 (0.85)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145085	0.94	BCL2L1 (0.87)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145375	0.94	BCL2L1 (0.87)	BCL2L1BCL2BADBCL2L2BCL2L11
Navitoclax SCHEMBL15005512	0.94	BCL2L1 (1.00)	BCL2L1BCL2BADBCL2L2BCL2L11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021000899-A1	A PHARMACEUTICAL COMBINATION CONTAINING mTOR INHIBITOR AND USE THEREOF	ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN)	2021-01-07	—	—	WO	disclosed