Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22859140 | 0.92 | MAP4K1 (0.57) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858763 | 0.90 | MAP4K1 (0.72) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29911361 | 0.89 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858710 | 0.89 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859127 | 0.88 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858778 | 0.87 | JAK2 (0.54) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL28713785 | 0.84 | MAP4K1 (0.55) | MAP4K1JAK2JAK1JAK3SYK | |
| SCHEMBL22859025 | 0.83 | MAP4K1 (0.49) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859128 | 0.83 | MAP4K1 (0.65) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858900 | 0.83 | MAP4K1 (0.49) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |