Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609161 | 1.00 | MAP4K1 (0.51) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859129 | 0.91 | MAP4K1 (0.55) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22858844 | 0.90 | MAP4K1 (0.52) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859141 | 0.89 | MAP4K1 (0.55) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22858833 | 0.89 | MAP4K1 (0.57) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859132 | 0.89 | MAP4K1 (0.53) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859002 | 0.88 | MAP4K1 (0.51) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22858769 | 0.88 | MAP4K1 (0.64) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859138 | 0.88 | MAP4K1 (0.52) | MAP4K1ABL1SYKAXLMERTK | |
| SCHEMBL22859133 | 0.88 | MAP4K1 (0.52) | MAP4K1ABL1SYKAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |